Chondrocytes- precursor cells for cartilage.
Thanatophoric dysplasia- growth plates of the rib limb bones fail to proliferate. This is a lethal mutation because the ribs can not support breathing. This is the effect of prematurely activating the STAT pathway.
Cadherins- a class of proteins that are calcium dependent adhesion molecules.
Karyokinesis- the mitotic division of the cell's nucleus. The mechanical agent of karyokinesis is the mitotic spindle.
Commitment- describes a state in which a cell's development fate has become restricted even though it is not yet displaying overt changes.
Determination- the second and irreversible stage of cell or tissue commitment in which the cell or tissue is capable of differentiating autonomously even when placed into a non neutral environment.
Specification- the first stage of commitment of cell or tissue fate during which the cell or tissue is capable of differentiating autonomously when placed in an environment that is neutral with respect to the developmental pathway at the stage.
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